Fig. 1.

Biomarker discovery phase of candidate miRNAs for predicting response to FOLFOX-based adjuvant chemotherapy in primary tumors from CRC patients. A Box plot of 10 candidate miRNAs for predicting the response to FOLFOX in CRC patients. FC and the P value of all candidate miRNAs were > 1.5 and < 0.05, respectively. * P < 0.05. ** P < 0.01. B ROC curve values for 10-miRNA panel for predicting response to FOLFOX in the discovery cohort (AUC = 0.88). C In discovery cohort, Kaplan-Meier curves of the recurrence-free survival for patients with 10-miRNA panel high (n = 32) or low (n = 39). ROC, Receiver operating characteristics; AUC, area under the curve; HR, hazard ratio; CI, confidence interval