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. 2023 Jan 6;13:1077644. doi: 10.3389/fendo.2022.1077644

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Copyright © 2023 Mighty, Rubio-Navarro, Shi, Zhou, Flores-Bellver, Heissel, Onwumere, Einbond, Gharbaran, Casper, Benito-Martin and Redenti

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation of JUP as a potential biomarker for diabetic retinopathy. JUP protein levels in retinal EVs (A) and urinary EVs (B) from Non-diabetic and Diabetic patients, obtained from the proteomic datasets. (C) JUP, CD63, CD81 and Pan-Actin levels in urinary EVs pooled from Non-DR, DR and Non-Diabetic patients. Each lane contains 30ug of EV proteins obtained from a pool of three independent samples. A network diagram representing protein-protein interaction showing (D) proteins that are involved in the organization and disruption of anchoring junction and (E) proteins involved in the development of vasculature. (F) Prediction analysis to determine protein subcellular localization. Pathway (G) and biological process (H) enrichment analysis of shared proteins between DR.EVs and DR.UrEVs.