Table 2.

Human urine patients’ samples information, including gender, age, diabetes (Yes or No), ethnicity, application of the samples, diabetic status, diagnosis and glycated hemoglobin levels (A1C).

Age	Gender	Diabetes	Ethnicity	Application	Diabetic Status	Diagnosis	A1C (%)
75	Male	YES	Caucasian	Fundus No DR Fig.3 - Urinary EVs isolation	No Diabetic Retinopathy	DM Type II	6.2
51	Male	YES	Caucasian	Fundus DR Fig.3 - Urinary EVs isolation	Severe NPDR	DM Type I	10.2
65	Male	YES	Caucasian	Urinary EVs Isolation	Severe NRPD	DM Type I	8.4
38	Male	YES	Caucasian	Urinary EVs Isolation, TEM, qPCR	Severe NRPD	DM Type I	8.2
42	Male	YES	Caucasian	Urinary EVs Isolation	No Diabetic Retinopathy	DM Type I	8.6
34	Female	YES	Hispanic	Urinary EVs Isolation	No Diabetic Retinopathy	DM Type I	7.1
36	Male	YES	Caucasian	Urinary EV isolation	Mild NRPD	DM Type I	7.8
46	Male	YES	Caucasian	Urinary EVs Isolation	Mild NRPD	DM Type I	8.5
38	Male	YES	Caucasian	Urinary EVs Isolation	Mild NRPD	DM Type I	7.1
48	Male	YES	Unknown	Urinary EVs isolation, NTA and proteomic analysis	Severe NPDR	DM Type I, CSME	10.1
35	Male	YES	Unknown	Urinary EVs isolation, NTA and proteomic analysis	Severe NPDR	DM Type I	8.2
46,2 ± 13,2
46	Male	NO	Caucasian	Urinary EVs isolation, NTA and proteomic analysis	Non Diabetic	NA	NA
52	Male	NO	Caucasian	Urinary EVs isolation, NTA and proteomic analysis	Non Diabetic	NA	NA

EVs, Extracellular vesicles; NTA, Nanoparticle tracking analysis; DM, Diabetes Mellitus; DR, Diabetic Retinopathy; NPDR, Non-proliferative diabetic retinopathy; CSME, Clinically Significant Macular Edema; NA, Not applicable. Average ± standard dev. included below age column.