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. 2023 Jan 20;435(5):167973. doi: 10.1016/j.jmb.2023.167973

Figure 5.

Figure 5

Mutations on nsp12 and nsp14 that correlate with a higher mutational load. (A) V435 and P918 (green) are on the region of nsp12 (red) that interacts with nsp14 (orange) to form a trans dimer for proofreading (PDB code: 7EGQ). (B-E) PDB code: 7EIZ. (B) G228 (green) is on the region of nsp12 (red) that interacts with nsp9 (blue). (C) V330, V675 and S384 (green) are on the interaction region between nsp12 (red) and nsp8 (blue). (D) H26, A23 and M57 (green) on nsp14 (orange) that interact with nsp10 (blue). (E) Y154 (green) on nsp14 (orange) interacts with nsp12 (red). (F) M501 (green) is on the region of nsp14 (orange) that interacts with nsp12 (magenta) to form a trans dimer for proofreading (PDB code: 7EGQ).