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. 2023 Jan 20;27:29. doi: 10.1186/s13054-023-04322-y

Table 1.

Summary of norepinephrine equivalent formulas

Author Year Journal Calculation
Patel et al. [22] 2002 Anesthesiology Norepinephrine dose (µg/min) + epinephrine dose (µg/min) + 1/4 × dopamine dose (µg/kg/min)
Russell et al. [13] (VASST) 2008 New England Journal of Medicine Norepinephrine dose (µg/min) + 1/2 × dopamine dose (µg/kg/min) + epinephrine dose (µg/min) + 1/10 × phenylephrine dose (µg/min)
Brown et al. [12] 2013 Chest Norepinephrine dose (µg/kg/min) + epinephrine dose (µg/kg/min) + 1/100 × dopamine dose (µg/kg/min) + 5 × vasopressin dose (U/min) + 0.45 × phenylephrine dose (µg/kg/min)
Ralib et al. [23] 2013 Clinical Nephrology Norepinephrine dose (μg/min) + 500 × vasopressin dose (U/min) + epinephrine dose (μg/min) + 1/3 × phenylephrine dose (μg/min) + 1/100 × dopamine dose (μg/min)
Gutsche et al. [21] 2017 Anesthesia & Analgesia Norepinephrine dose (μg/min) + 1/2 × dopamine dose (μg/kg/min) + epinephrine dose (μg/min) + 1/10 × phenylephrine dose (μg/min) + 200 × vasopressin dose (U/min)
Khanna et al. [15] (ATHOS-3) 2017 New England Journal of Medicine Norepinephrine dose (µg/kg/min) + epinephrine dose (µg/kg/min) + 1/150 × dopamine dose (µg/kg/min) + 1/10 × phenylephrine dose (µg/kg/min) + 2.5 × vasopressin dose (U/min)
Laterre et al. [16] (SEPSIS-ACT) 2019 JAMA Norepinephrine dose (µg/min) + epinephrine dose (µg/min) + 1/100 × dopamine dose (µg/min) + 1/2.2 × phenylephrine dose (µg/kg/min)
Goradia et al. [20] 2021 Journal of Critical Care Norepinephrine dose (µg/kg/min) + epinephrine dose (µg/kg/min) + 1/10 × phenylephrine dose (µg/kg/min) + 1/100 × dopamine dose (µg/kg/min) + 1/8 × metaraminol (µg/kg/min) + 2.5 × vasopressin dose (U/min) + 10 × angiotensin II dose (µg/kg/min)
Our manuscript 2022 Norepinephrine dose (µg/kg/min) + epinephrine dose (µg/kg/min) + 1/100 × dopamine dose (µg/kg/min) + 0.06 × phenylephrine dose (µg/kg/min) + 2.5 × vasopressin dose (U/min) + 0.0025 × angiotensin II dose (ng/kg/min) + 10 × terlipressin dose (µg/kg/min) + 0.2 × methylene blue dose (mg/kg/h) + 8 × metaraminol dose (µg/kg/min) + 0.02 × hydroxocobalamin dose (g) + 0.4 × midodrine dose (µg/kg/min)