|
Cohort name Country Reference Follow‐up Funding |
Original Cohort (N total) Exclusion criteria Study population (n, sex and age at baseline) |
Ascertainment of outcome |
Exposure groups n |
Incident cases | Model covariates | Results |
|---|---|---|---|---|---|---|
|
NIH‐AARP Diet and Healthy Study USA O'Grady et al. (2014) Prospective Cohort 10 yr Public |
N = 566,398 Population Sampled: members of the American Association of Retired Persons (AARP), aged 50–71 yr old. Excluded: participants with proxy respondents, reported poor health or end stage renal disease, with a previous diagnosis of cancer other than NMSC, with extreme or missing values for total energy intake or Se intake. n = 482,807 Sex (% F): 40.34 Ethnicity: Majority white Age (yr, range): 50–71 |
Incident thyroid cancer cases identified via linkage of the NIH‐AARP cohort membership to state cancer registries and the National Death Index; defined according to the International Classification of Disease for Oncology, Third Edition (ICD‐O‐3) |
Se intake assessed through a SFFQ Se intake (μg/day mean ± SD): 94.0 ± 42.9 Quintiles of Se intake (μg/day, median) Q1: 47 Q2: 68.4 Q3: 86.6 Q4: 108.6 Q5: 150.1 n, per quintile of intake Q1: 96,561 (22,396 M) Q2: 96,562 (39,795 M) Q3: 96,561 (60,176 M) Q4: 96,562 (77,287 M) Q5: 96,561 (88,290 M) |
592 incident thyroid cancer cases n thyroid cancer cases, F/M, per quintile of intake Q1: 119/19 Q2: 106/25 Q3: 66/49 Q4: 29/68 Q5: 15/96 |
Model 1 (M1) ‐ age Model 2 (M2) – M1 + sex, calories, smoking status, race, education, BMI, and physical activity. Model 3 (M3) – M2 + vitamin C, vitamin E, beta‐carotene, and folate. |
Incidence of thyroid cancer, HRs (95% CI) M1 Q1 (ref): 1 Q2: 0.96 (0.75, 1.22) Q3: 0.85 (0.66, 1.09) Q4: 0.72 (0.56, 0.94) Q5: 0.83 (0.65, 1.07) M2 Q1 (ref): 1 Q2: 1.00 (0.79, 1.28) Q3: 0.99 (0.76, 1.29) Q4: 1.00 (0.75, 1.33) Q5: 1.23 (0.92, 1.65) M3 Q1 (ref): 1 Q2: 1.07 (0.83, 1.36) Q3: 1.07 (0.81, 1.40) Q4: 1.10 (0.82, 1.48) Q5: 1.35 (0.99, 1.84) |
CI: confidence interval; F: females; HR: hazard ratio; M: males; NIH‐AARP: National Institutes of Health‐American Association of Retired Persons – Diet and Health Study; Qx: quintile x; SD: standard deviation; SFFQ: semi‐quantitative food frequency questionnaire; USA: United States of America; yr: year.