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. 2023 Jan 20;21:36. doi: 10.1186/s12967-023-03885-2

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The system role of MOTS-c. MOTS-c acts on multiple systems such as muscle, adipose tissue and immune system through blood circulation. MOTS-c can increase muscle's motor function and insulin sensitivity, promote the conversion from white adipose tissue to brown adipose tissue while activating brown adipose tissue, additionally decreasing the expression of inflammatory factors and increasing the anti-inflammatory effect. Besides, MOTS-c is beneficial for antioxidant stress, metabolic homeostasis, exercise capacity and healthy aging