Table 3.

Optimization of reaction for the semi-synthesis of asperpyrroindotide A (8)^a

Entry	Solvent	Equiv b	Yieldc/%
1	Dichloromethane	2	4.9
2	Ethanol	2	0
3	Acetone	2	0
4	1,4-Dioxane	2	0
5	Dichloromethane	4	15.6
6	Dichloromethane	6	19.6
7	Dichloromethane	8	19.6

^a8 Equiv trifluoroacetic acid (TFA) catalyst was used in all cases, and the reaction time was 1 h

^bThe equiv of meta-chloroperoxybenzoic acid (m-CPBA)

^cThe yield of asperpyrroindotide A (8)