Table 1.
Simultaneous effects on different NOS isoforms exerted by polyphenols.
| Compound Tested | In Vitro/In Vivo Model | Effects | References |
|---|---|---|---|
| Resveratrol | human melanoma A375 cells | increase of iNOS, eNOS, and nNOS expression | [145] |
| human glaucomatous trabecular meshwork (TM) cells | decrease of iNOS expression, increase of eNOS expression | [146] | |
| human endothelial HUVEC cells | increase of eNOS expression, no effects on iNOS | [147] | |
| aorta from rats under high-fructose corn syrup intervention | decrease of iNOS expression, increase of eNOS expression | [149] | |
| type-2 diabetic mice | decrease of iNOS expression, increase of eNOS expression | [150] | |
| rat model of myocardial infarction | increase of eNOS and iNOS expression | [151] | |
| rat liver, kidney, and ileum | increase of eNOS and iNOS expression | [152] | |
| Piceatannol | rat H9c2 cardiomyocytes challenged with H2O2 | activation of PI3K-Akt-eNOS pathway, decrease of iNOS expression | [148] |
| Quercetin | liver of juvenile blunt-snout bream fed a high-fat diet | decrease of iNOS expression, increase of eNOS expression | [153] |
| Rutin | rat liver after ischemia-reperfusion (I/R) | decrease of iNOS expression, increase of eNOS expression | [154] |
| EGCG | rats with gastric ulceration | decrease of iNOS expression, increase of eNOS expression | [155] |
| epicatechin | bovine aortic endothelial cell challenged with oxLDL | decrease of iNOS expression, increase of eNOS expression | [156] |
| lycochalcone C | rat H9c2 cardiomyocytes challenged with LPS | upregulation of the PI3K/Akt/eNOS signaling pathway, decrease of iNOS expression | [157] |
| curcumin | cavernous tissues from diabetic rats | increase of nNOS and eNOS expression, decrease of iNOS expression | [158] |