. 2023 Jan 12;13(2):262. doi: 10.3390/ani13020262

Table 8.

Effects of NAC administration on mRNA expression of MMP3, MMP13, REG3G, TGF-β, and GJA1 in liver, spleen, lung, lymph node, and gastrocnemius muscle in piglets infected with PEDV.

Items	−PEDV		+PEDV		SEM	p-Value
Items	−NAC	+NAC	−NAC	+NAC	SEM	PEDV	NAC	PEDV × NAC
MMP3
Lung	1.00	1.15	2.37	2.17	0.13	<0.001	0.88	0.21
Spleen	1.00 ^b	0.39 ^c	0.33 ^c	3.13 ^a	0.13	<0.001	<0.001	<0.001
Lymph node	1.00 ^c	1.63 ^b	2.68 ^a	1.54 ^b	0.15	<0.001	0.09	<0.001
Gastrocnemius	1.00 ^bc	1.60 ^a	1.18 ^b	0.89 ^c	0.09	0.01	0.09	<0.001
MMP13
Liver	1.00 ^b	1.45 ^a	1.54 ^a	1.35 ^a	0.10	0.05	0.23	<0.001
Lung	1.00	1.22	1.97	1.93	0.11	<0.001	0.43	0.26
Spleen	1.00 ^a	0.87 ^a	0.58 ^b	0.99 ^a	0.07	0.03	0.04	<0.001
Lymph node	1.00 ^c	1.45 ^a	1.30 ^ab	1.17 ^bc	0.08	0.93	0.04	<0.001
Gastrocnemius	1.00 ^b	0.84 ^b	0.91 ^b	1.59 ^a	0.08	<0.001	<0.001	<0.001
REG3G
Spleen	1.00 ^c	1.47 ^b	1.75 ^b	3.72 ^a	0.16	<0.001	<0.001	<0.001
Gastrocnemius	1.00 ^c	1.07 ^bc	1.63 ^a	1.29 ^b	0.09	<0.001	0.13	0.03
TGF-β
Liver	1.00	1.26	0.63	0.82	0.08	<0.001	0.01	0.63
Lung	1.00	0.87	0.98	0.81	0.06	0.52	0.02	0.70
Spleen	1.00 ^a	0.75 ^b	0.71 ^b	0.98 ^a	0.06	0.65	0.91	<0.001
Lymph node	1.00 ^a	0.95 ^ab	0.77 ^b	1.01 ^a	0.07	0.24	0.18	0.04
Gastrocnemius	1.00 ^a	0.72 ^b	0.71 ^b	0.71 ^b	0.04	<0.001	<0.001	<0.001
GJA1
Liver	1.00 ^b	1.49 ^a	1.30 ^a	0.91 ^b	0.09	0.15	0.61	<0.001
Lung	1.00	1.05	0.82	0.86	0.08	0.02	0.55	0.90
Spleen	1.00 ^b	0.93 ^b	0.66 ^c	1.17 ^a	0.06	0.37	<0.001	<0.001
Lymph node	1.00	1.11	1.15	1.16	0.07	0.19	0.41	0.48
Gastrocnemius	1.00	1.33	0.88	1.10	0.08	0.03	<0.001	0.47

Values are mean and pooled SEM, n = 8; ^a,b,c Within a row, means with different superscripts differ, p < 0.05.