Table 7.

Characteristics of local plus systemic antibiotics administration alone or combined with other interventions in treating peri-implantitis.

Author(s), Year	Local Antibiotics +/− Combined Intervention	Systemic Antibiotics +/− Combined Intervention	Outcomes	Conclusion
Wang, 2021 [43]	Minocycline “Periocline” + OFD + SRP at 1, 3, 6 months	AMX (500 mg/8 h for 3 d)	BoP PPD	Systemic antibiotics in peri-implantitis management should provide benefits in clinical outcomes for up 12 mo. post-therapy
Esposito, 2019 [39]	MTZ 25% gel “Elyzol” + tetracycline hydrochloride “Ambramicine” + apically repositioned flap	AMX (50 mg/kg/d for 8 d) + SRP before surgery	PPD CAL REC	There were no baseline imbalances for plaque, marginal bleeding, PPD, CAL, and REC, and no differences after 2 years

Abbreviations: Day(s), “d”; Probing pocket depth, “PPD”; Bleeding on probing, “BoP”; Clinical attachment loss, “CAL”; Recession, “REC”; Amoxicillin, “AMX”; Metronidazole, “MTZ”; Scaling and root planing, “SRP”; Open flap debridement, “OFD”.