Figure A2.

(a) Levels of CoQ9 and CoQ10 were lower in a low CoQ diet compared to a normal chow diet. (b) Combined CoQ₉ and CoQ₁₀ measurements in BAT and liver of PDSS2^BKO and PDSS2^FL mice fed a normal chow diet, n = 5. CoQ levels in BAT of PDSS2^BKO are decreased to 50% of PDSS2^FL and unchanged in the liver. (c,d) Individual CoQ₉ and CoQ₁₀ measurements in tissues of PDSS2^BKO and PDSS2^FL mice fed a defined low CoQ diet, n = 4. H&E staining of (e) eWAT and (f) liver of PDSS2^FL and PDSS2^BKO animals show no notable morphological differences. Data represent mean ± SEM. Significance presented at * p < 0.05, ** p < 0.01, and *** p < 0.001 compared to controls or otherwise indicated.