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Febuxostat facilitates the degradation of kelch-like ECH-associated protein 1 (Keap1). (A,B) 3T3-L1 and C3H10T1/2 cells were cultured in the presence of cycloheximide with or without Omav or Febu for the indicated time period. Keap1 levels were analyzed by western blotting. β-actin served as a loading control. Relative changes in the band intensities normalized by respective loading controls are indicated.
