Figure 1.

The regulation of ACO1 is a potential mechanism of baicalein against iron accumulation. (A) The regulation network from the reported mechanisms of baicalein to the proteins that regulate intracellular iron. The reported and predictive regulation of proteins by baicalein was colored orange (up-regulated) or blue (down-regulated). The size of nodes is positively correlated with the number of pathways that the protein participates in. (B) The chemical structure of baicalein and the molecular docking result that baicalein binds to ACO1. The substrate binding site of ACO1 is shown as spheres. The iron–sulfur cluster was colored yellow (sulfur) and orange (iron). (C) IRP1 can be activated from ACO1 to promote intracellular iron accumulation.