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. 2022 Mar 31;34(1):70–77. doi: 10.1021/acs.bioconjchem.2c00077

Figure 2.

Figure 2

Impact of terminal functionalities on the supramolecular DNA architecture revealed by cryo-EM imaging. (a) Formation of unilamellar vesicles by self-assembly of ON1*ON2. (b) Coexistence of ribbons and vesicles after self-assembly of ON1*ON3. (c) Duplex ON1*ON4 assembles into ribbons only. (d) Self-assembly of ON1*ON5 leads to the formation of star-like nanoobjects (asterosomes). Conditions for (a–d): 1 μM each single strand, 10 mM sodium phosphate buffer pH 7.2, 0.1 mM spermine·4 HCl, 30 vol % ethanol; see Supporting Information for additional images.