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. 2022 Dec 24;12(1):33. doi: 10.3390/antiox12010033

Figure 1.

Figure 1

Polymorphonuclear neutrophil (PMN) reduction and myeloperoxidase (MPO) deficiency (Mpo−/−) alleviate inflammatory response after myocardial infarction (MI). (A) Schematic timeline of Ly6G antibody treatment, permanent left anterior descending artery (LAD) ligation (PI) and cardiac analyses: wildtype (WT) mice were treated with Ly6G antibodies 2 days before PI operation followed by cardiac investigations at days 2 and 7. (B) MPO plasma levels 2 and 8 days after PI assessed by ELISA. (C) Representative immunohistochemical Ly6G stainings (brown) of cardiac sections after 2 days of PI. Scale bar = 200 µm. (D) Quantitative analysis of Ly6G positive cells within the infarct and peri-infarct region 2 days after PI. n = 5/5/5/5; * p < 0.05, *** p < 0.001, **** p < 0.0001, ns = not significant; one way ANOVA test followed by appropriate post hoc test, mean ± SEM is shown.