Table 4.

The enzyme inhibition data of human carbonic anhydrase isoenzymes (hCA-I and -II) with the most active pyrazole, pyrazolo[1,5-a]pyrimidine derivatives, and Acetazolamide.

Compound No.	hCA-I		hCA-II
	IC50 (nM)	Ki (nM)	IC50 (nM)	Ki (nM)
3a	92.34	88.78	73.2	91.85
5a	137.99	176.21	161.22	144.27
6	168.84	153.46	130.29	145.58
9a	123.41	101.55	142.28	135.78
10a	153.45	143.59	121.98	139.37
ACZ a	994.78	1052.22	900.33	981.64

^a: Acetazolamide was used as a standard inhibitor for both CA-I and CA-II isoenzymes (hCA-I and -II).