Figure 8.

Binding modes of DM96, DM151, DM109, and DMC at the active site of hGSTP1-1. Carbon atoms of the studied curcumin derivatives are presented in orange, while carbon atoms of hGSTP1-1 amino-acid residues are depicted in light blue color. Oxygen atoms are red, nitrogen atoms dark blue, and fluorine atoms green. Hydrophobic interactions are presented with gray dashed lines and hydrogen bonds with dark blue lines. All distances represent averages over all MD production run snapshots for each complex and are provided in Å. Hydrogen atoms are omitted for reasons of clarity.