Figure 1.

Effect of PAC on body weight gain, food intake and organs weight. Mice were fed either a standard chow diet or a high-fat, high-sucrose diet (HFHS) ± 200 mg/kg polyphenol proanthocyanidin-rich fraction (PAC) body weight/day by gavage (HFHS + PAC) for 12 weeks. Chow diet and HFHS-fed mice were gavaged with a water vehicle. (A) body weight gain, (B) energy intake, (C) whole adipose tissue weight (as a total of collected fat pads) and (D) its tissue distribution, (E) liver and (F) gut weights were measured as described in Materials and Methods. Results are presented as mean ± SEM for n = 12–16 mice/group. ** p < 0.01, *** p < 0.001 vs. chows; # p < 0.05, ## p < 0.01, ### p < 0.001 vs. HFHS mice.