Table 3.
Differential Expression of miRNAs and NOX Isoforms in Models of Ischemia/Reperfusion Injury Legend: SD—Sprague Dawley; MI/R—Myocardial Ischemia/Reperfusion; LAD—Left Anterior Descending Coronary Artery; CI/R—Cerebral Ischemia/Reperfusion; ICA—Internal Carotid Artery; PCA—Posterior Cerebral Artery; MCA—Middle Cerebral Artery; ACA—Anterior Cerebral Artery; AD—Alzheimer’s Disease; APP—Amyloid Precursor Protein; PS1—Human Presenilin 1.
| Pathology | Model | miRNA Identified | NOX Regulation | Ref. |
|---|---|---|---|---|
| MI/R | SD rats LAD artery ligation for 30 min/reperfusion for 3 or 24 h | ↓ miR-145-5p | ↑ NOX1 | [58] |
| CI/R | SD rats occlusion of ICA, PCA, MCA, ACA for 2h/reperfusion for 24 h | ↓ miR-126a-5p | ↑ NOX2 | [66] |
| CI/R | SD rats occlusion of ICA, PCA, MCA, ACA for 2 h/reperfusion for 24 h | ↓ miR-454 | ↑ NOX4 | [67] |
| CI/R | SD rats occlusion of ICA, PCA, MCA, ACA for 2 h/reperfusion for 24 h | ↓ miR-652 | ↑ NOX2 | [69] |
| CI/R | SD rats occlusion of MCA for 2 h/reperfusion for 24 h | ↓ miR-92b-3p | ↑ NOX4 | [82] |
| CI/R | SD rats occlusion of ICA for 2 h/reperfusion for 24h | ↓ miR-523-3p | ↑ NOX2 | [68] |
| AD | APPswe/PS1dE9 mice APP/PS1 mice, 6 mos old | ↓ miR-204-3p | ↑ NOX4 | [71] |