Figure 7.

Results of the ex vivo bioadhesion assays for hydrogel combination product samples containing non-irradiated or gamma-irradiated (i.e., 31 kGy) cellular extracts. Panels (A,B) express different parameters of the same force profiles (i.e., analysis of unchallenged samples). Similarly, panels (C,D) express different parameters of the same force profiles (i.e., analysis of H₂O₂-challenged samples). (A) Mean force of adhesion values of the various hydrogel samples compared to PBS. (B) Mean work of adhesion values of the same hydrogel samples compared to PBS. (C) Mean force of adhesion values of the various H₂O₂-challenged hydrogel combination product samples compared to unchallenged PBS and unchallenged linear HA controls. (D) Mean work of adhesion values of the same H₂O₂-challenged hydrogel samples compared to unchallenged PBS and unchallenged linear HA controls. Significant statistical differences (i.e., * or p value < 0.05), very significant statistical differences (i.e., ** or 0.001 < p value < 0.01), or extremely significant statistical differences (i.e., **** or p value < 0.0001) were found between the presented mean values. HA, hyaluronic acid; kGy, kiloGray; LYO-LYS, lyophilized lysate fraction; LYO-MEM, lyophilized membrane fraction; LYO-PLA, lyophilized placebo sample; LYO-SN, lyophilized soluble fraction; LYO-WC, lyophilized whole-cell fraction; N, Newton; PBS, phosphate-buffered saline.