Figure 1.

Methods for modelling 3D cell aggregates. (A) Continuum model of a colon cancer organoid [10]. Colors indicate the density of different cell types. SC: stem cell, CP: committed progenitor, TD: terminal differentiated cell. (B) Individual cell-based model of an intestinal organoid [11]. Cells are represented by overlapping spheres. Colors indicate different cell types. PC: Paneth cell, GC: goblet cell, EC: enterocyte. Cell motion is confined by a polymer network enveloping all cells (grey). (C) Vertex model of an optical-cup [12]. Cells are represented by prisms that form a dense surface. (D) 3D Voronoi tessellation of a tumor spheroid [13]. The cell shape is derived from the neighborhood relations of experimentally detected cell centers (upper right). Individual cells are indicated by different color.