Table 1.

Different 3D COM approaches (compare also Norfleet et al. [9]).

Organoid Described by:	Example	Pros	Cons
Spatio-temporal distribution of cell densities	Figure 1A	fast computation	Properties of individual cells cannot be addressed
Objects: spherical cells, polymer network	Figure 1B	simple interaction scheme	tissue mechanics hard to assess
Objects: prism-like cells	Figure 1C	well-defined tissue mechanics	limited cell mobility
Voronoi-polyhedrons generated from cell center distributions	Figure 1D	flexible cell shape direct from experiments	cell–cell interaction by center-center interaction