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. 2023 Jan 4;12(1):86. doi: 10.3390/antibiotics12010086

Table 4.

Amino acid substitutions in gyrase proteins in C. difficile isolates from SAC.

Isolate Protein Amino Acid Substitutions
19S0136 GyrA Thr-82-Val *
Lys-413-Asn
GyrB Gln-160-His
Ser-366 #-Val
Ser-416-Ala *
19S0160 GyrB Val-130-Ile
19S0161 GyrB Val-130-Ile

* Amino acid substitutions that were reported to confer fluoroquinolone resistance [10]. # Another amino acid substitution at this position (Ser-366-Ala) was reported to confer fluoroquinolone resistance [10].