Table 5.

Variables: Exposures and Outcomes

EXPOSURE	DEFINITION
Primary Exposure
Prophylaxis Antimalarial Use (Chloroquine and Proguanil (C-P))	Documentation of combined C-P regimen use during pregnancy in obstetrical record
Administration throughout pregnancy	Combined C-P regimen: Proguanil 200mg daily and Chloroquine 5mg/kg of body weight weekly -i.e. 300mg base
Secondary Exposure
HIV Positive	Documentation of positive maternal HIV diagnostic test result during or before pregnancy
HIV Negative	Documentation of negative maternal HIV diagnostic test result during or before pregnancy were considered HIV unexposed
On Antiretroviral (ART)	Births to Women Living with HIV with ART exposure before delivery
ART naive	Births to Women Living with HIV with no ART exposure before delivery
BIRTH OUTCOME	DEFINITION
Primary Outcome
Preterm Delivery (PTD)	Birth at gestational age less than 37 weeks
Very Preterm Delivery (vPTD)	Birth at gestational age less than 34 weeks
Neonatal death (NNTD)	Deaths before 28 days of age among neonates who had never left the hospital
Still birth (SB)	Fetal death - Apgar Scores of 0,0, and 0
Small for Gestational Age (SGA)	Birth weight below the 10th percentile for gestational age
Very Small for Gestational Age (vSGA)	Birth weight below the 3rd percentile for gestational age
	Secondary Analysis
PTD, vPTD, NNTD, SB, SGA, and vSGA	Birth outcomes by HIV status and ART use