. 2023 Jan 10;12(1):137. doi: 10.3390/antibiotics12010137

Table 1.

Selective serotonin reuptake inhibitors (SSRIs) with anticancer properties.

Compound	Mechanism of Action	Cell Line	Reference
Citalopram Escitalopram	Modulation of NFκB-signaling, ROS formation	HepG2 hepatocellular carcinoma cell line, A549 and H460 non-small lung cancer cell lines	[53,54]
Citalopram Escitalopram	Disruption of mitochondrial membrane potential	Burkitt lymphoma cell lines	[55]
Fluoxetine	Modulation of NFκB-signaling	CL1-5-F4 human lung adenocarcinoma cell line	[56]
	Modulation of NFκB-signaling	OVCAR-3 human epithelial ovarian cancer cell line	[57]
	Modulation of AKT/mTOR pathway	A549 and H460 non-small lung cancer cell lines	[58]
	Disruption of mitochondrial membrane potential	HT29 and CaCo-2 human colon adenocarcinoma cell lines, Burkitt lymphoma cell lines	[56,59]
	Mitochondrial Ca²⁺-overload	HeLa human cervical carcinoma cell line	[60]
Paroxetine	Modulation of AKT-signaling	HCT116 and HT29 human colon adenocarcinoma	[61]
Paroxetine	Disruption of mitochondrial membrane potential	Burkitt lymphoma cell lines	[55]
Sertraline	Modulation of mTOR signaling	MCF-7 human breast adenocarcinoma cell line	[62]
	Modulation of mTOR signaling	SGC-7901/DDP gastric cancer cell line	[63]
	Modulation of AKT signaling	A375 human melanoma cell line	[64]
	Ca²⁺-overload, ROS formation	Prostate cancer cell lines	[65,66]
	Ca²⁺-overload, ROS formation	MG63 human osteosarcoma cell line	[67]