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. 2023 Jan 12;10(1):111. doi: 10.3390/bioengineering10010111

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Normal ocular surface and limbus. (A) The corneoscleral limbus contains the palisades of Vogt (PVs), which have a length of 0.31 mm and a width of 0.04 mm and are typically more detectable on the superior and inferior sections of cornea. (B) Corneoscleral junction with magnification showing PVs. (C) The PVs contain different cells, such as melanocytes, mesenchymal stem cells, and immune cells. These cells, along with neurovasculature, provide growth factors, nutrients, and structural support to promote proper LESC proliferation and differentiation (LESC: limbal epithelial stem cell, TAC: transient amplifying cell, MSC: mesenchymal stem cell). Modified with permission from [14].