Table 1.
Minimum inhibitory concentrations (MIC) (μg/mL) and fractional inhibitory concentration indices (FICI) of kuraridin (Kur) and epicatechin gallate (ECG) against community-associated (CA) and hospital-associated (HA) MRSA strains.
| Strains | Category | MIC Alone (μg/mL) | MIC Combine (μg/mL) | FIC | FICI | Outcome | |||
|---|---|---|---|---|---|---|---|---|---|
| ECG | Kur | ECG | Kur | ECG | Kur | ||||
| W44 | CA MRSA | 512 | 8 | 2 | 2 | 0.004 | 0.25 | 0.25 | Synergy |
| W45 | CA MRSA | 512 | 8 | 1 | 4 | 0.002 | 0.5 | 0.50 | Synergy |
| W46 | CA MRSA | 512 | 8 | 8 | 4 | 0.015 | 0.5 | 0.52 | Additive |
| W47 | CA MRSA | 512 | 8 | 2 | 4 | 0.004 | 0.5 | 0.50 | Synergy |
| W48 | CA MRSA | 512 | 8 | 1 | 4 | 0.002 | 0.5 | 0.50 | Synergy |
| W101 | CA MRSA | 512 | 8 | 1 | 4 | 0.002 | 0.5 | 0.50 | Synergy |
| W103 | CA MRSA | 512 | 8 | 1 | 4 | 0.002 | 0.5 | 0.50 | Synergy |
| W106 | CA MRSA | 512 | 8 | 1 | 2 | 0.002 | 0.25 | 0.25 | Synergy |
| W113 | CA MRSA | 512 | 8 | 1 | 4 | 0.002 | 0.5 | 0.50 | Synergy |
| W114 | CA MRSA | 512 | 8 | 1 | 4 | 0.002 | 0.5 | 0.50 | Synergy |
| ST30 | CA MRSA | 512 | 8 | 0.25 | 4 | 0.0004 | 0.5 | 0.50 | Synergy |
| W231 | HA MRSA | 512 | 4 | 8 | 1 | 0.016 | 0.25 | 0.27 | Synergy |
| W232 | HA MRSA | 512 | 8 | 4 | 2 | 0.008 | 0.25 | 0.26 | Synergy |
| W233 | HA MRSA | 512 | 4 | 2 | 2 | 0.004 | 0.5 | 0.50 | Synergy |
| W234 | HA MRSA | 512 | 8 | 1 | 4 | 0.002 | 0.5 | 0.50 | Synergy |
| W235 | HA MRSA | 512 | 8 | 1 | 4 | 0.002 | 0.5 | 0.50 | Synergy |
| W238 | HA MRSA | 512 | 8 | 1 | 4 | 0.002 | 0.5 | 0.50 | Synergy |
| W239 | HA MRSA | 512 | 8 | 1 | 4 | 0.002 | 0.5 | 0.50 | Synergy |
| W240 | HA MRSA | 512 | 8 | 4 | 4 | 0.008 | 0.5 | 0.51 | Additive |
| ST239 | HA MRSA | 512 | 8 | 2 | 4 | 0.004 | 0.5 | 0.50 | Synergy |
| ATCC 25923 | MSSA | 512 | 8 | 4 | 4 | 0.008 | 0.5 | 0.51 | Additive |