Table 2.
Minimum inhibitory concentrations (MIC) (μg/mL) and fractional inhibitory concentration indices (FICI) of kuraridin (Kur) and epicatechin gallate (ECG) with or without antibiotics against the laboratory S. aureus strains with known antibiotic-resistant mechanisms.
| MIC Alone (μg/mL) | MIC Combine (μg/mL) | FIC | FICI | Outcome | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Strains/ Antibiotics (An) |
ECG | Kur | An | ECG | Kur | An | ECG | Kur | An | ||
| 1199B | 512 | 16 | 16 | 32 | 4 | 8 | 0.06 | 0.25 | 0.5 | 0.81 | Additive |
| Ciprofloxacin | 512 | 16 | - | 32 | 4 | - | 0.06 | 0.25 | - | 0.31 | Synergy |
| RN4220 | 512 | 8 | 256 | 8 | 2 | 128 | 0.01 | 0.26 | 0.5 | 0.76 | Additive |
| Erythromycin | 512 | 8 | - | 8 | 2 | - | 0.01 | 0.26 | 0.5 | Synergy | |
| APH2 | 512 | 8 | 512 | 0.25 | 2 | 16 | 0.0005 | 0.25 | 0.0312 | 0.28 | Synergy |
| Gentamicin | 512 | 8 | - | 0.5 | 2 | - | 0.0009 | 0.25 | - | 0.25 | Synergy |
| APH3 | 512 | 8 | 256 | 0.5 | 2 | 128 | 0.0009 | 0.25 | 0.5 | 0.75 | Additive |
| Kanamycin | 512 | 8 | - | 0.5 | 2 | - | 0.0009 | 0.25 | 0.25 | Synergy | |
| ANT4 | 512 | 8 | 64 | 4 | 2 | 8 | 0.0007 | 0.25 | 0.125 | 0.38 | Synergy |
| Fusidic acid | 512 | 8 | - | 16 | 2 | 0.03 | 0.25 | 0.28 | Synergy | ||