Table 5.
Minimum inhibitory concentrations (MIC) (μg/mL) and fractional inhibitory concentration indices (FICI) of kuraridin and epicatechin gallate (ECG) with antibiotics against clinical MRSA strains.
| Strains | MIC Alone | MIC Combine | FIC | FICI | Outcome | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ECG | Kur | Van | ECG | Kur | Van | ECG | Kur | Van | |||
| W44 | 512 | 8 | 1 | 0.25 | 2 | 0.5 | 0.0004 | 0.25 | 0.5 | 0.75 | Additive |
| W45 | 512 | 8 | 1 | 0.25 | 2 | 0.5 | 0.0004 | 0.25 | 0.5 | 0.75 | Additive |
| W46 | 512 | 8 | 1 | 1 | 4 | 0.5 | 0.002 | 0.5 | 0.5 | 1.00 | Additive |
| W47 | 512 | 8 | 1 | 0.25 | 2 | 0.25 | 0.0004 | 0.25 | 0.25 | 0.50 | Synergy |
| W48 | 512 | 8 | 1 | 1 | 2 | 0.5 | 0.002 | 0.25 | 0.5 | 0.75 | Additive |
| W231 | 512 | 8 | 1 | 0.25 | 1 | 0.5 | 0.0004 | 0.125 | 05 | 0.62 | Additive |
| W232 | 512 | 8 | 1 | 8 | 2 | 0.5 | 0.03 | 0.25 | 0.5 | 0.75 | Additive |
| W233 | 512 | 8 | 1 | 8 | 2 | 0.5 | 0.03 | 0.25 | 0.5 | 0.75 | Additive |
| W238 | 512 | 8 | 1 | 0.25 | 2 | 0.5 | 0.0004 | 0.25 | 0.5 | 0.75 | Additive |
| W239 | 512 | 8 | 1 | 0.5 | 2 | 0.5 | 0.0009 | 0.25 | 0.5 | 0.75 | Additive |
| ST30 | 512 | 8 | 1 | 0.25 | 1 | 0.5 | 0.0004 | 0.125 | 0.5 | 0.62 | Additive |
| ST239 | 512 | 8 | 1 | 0.25 | 1 | 0.5 | 0.0004 | 0.125 | 0.5 | 0.62 | Additive |