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. 2022 Nov 2;37(3):217–226. doi: 10.4103/ijnm.ijnm_111_21

Table S1.

List of first and second order unfiltered parameters extracted from PET and CT images on LifeX software

First order Second order
1.Conventional/Discretized
CONV/DISCRET_min, mean, max, std)
CONV/DISCRET_peak 0.5 mL
CONV/DISCRET_peak 1 mL
CONV/DISCRET_CAS
CONV/DISCRET_TLG (for TP, MN)
CONV/DISCRET_RIM_(min, mean, sd, max)
CONV/DISCRET_(Q1, Q2, Q3)
2. Histogram (HISTO): The histogram features consist of simple statistics that are asso- ciated with pixel values in images while the spatial patterns of the pixel values are not included. Entropy and energy are calculated.
HISTO_Skewness
HISTO_Kurtosis
HISTO_Entropy_log10
HISTO_Entropy log2
HISTO_Energy
AUC_CSH
3.Shape value
Shape_Sphericity
Shape_Compacity
Shape_Volume_mL
Shape_Volume_vx
Shape_SurfaceArea
1.Gray Level Co-occurrence Matrix (GLCM)
GLCM_Homogeneity
GLCM_Energy
GLCM_Contrast
GLCM_Correlation
GLCM_Entropy
GLCM_Dissimilarity
2.Gray-Level Run Length Matrix (GLRLM)- The GLRLM describes the number of the consecutive pixels of the same gray-level value for 4 directions in 2D or 13 directions in 3D
GLRLM_SRE (Short run emphasis)
GLRLM_LRE (Long run emphasis)
GLRLM_LGRE (Low gray-level run emphasis)
GLRLM_HGRE (High gray-level run emphasis)
GLRLM_SRLGE (Short run low gray-level emphasis)
GLRLM_SRHGE (Short run high gray-level emphasis)
GLRLM_LRGLE (Long run low gray-level emphasis)
GLRLM_LRHGE (Long run high gray-level emphasis)
GLRLM_GLNU (Gray-level non-uniformity)
GLRLM_RLNU (Run length non-uniformity)
GLRLM_RP (Run percentage)
3.Neighborhood Gray-Level Different Matrix (NGDLM): Described the difference of grey levels between adjacent voxels in 2D and 26 in 3D
NGLDM_Coarseness
NGLDM_Contrast
NGLDM_Busyness
4. Gray-Level Zone Length Matrix (GLZLM) : Describes the number of homogenous zones of the same grey level value in 2D or 3D
GLZLM_SZE (Short-zone emphasis)
GLZLM_LZE (Long-zone emphasis)
GLZLM_LGZE (Low gray-level zone emphasis)
GLZLM_HGZE (High gray-level zone emphasis)
GLZLM_SZLGE (Short-zone low gray-level emphasis)
GLZLM_SZHGE (Short-zone high gray-level emphasis)
GLZLM_LZGLE (Long-zone low gray-level emphasis)
GLZLM_LZHGE (Long-zone high gray-level emphasis)
GLZLM_GLNU (Gray-level non-uniformity for zone)
GLZLM_ZLNU (Zone length non-uniformity)
GLZLM_ZP (Zone percentage)

HISTO: Histogram, GLCM: Gray level co-occurrence matrix, GLRLM: Gray-level run-length matrix, SRE: Short-run emphasis, LRE: Long-run emphasis, LGRE: Low gray-level run emphasis, HGRE: High gray-level run emphasis, SRLGE: Short-run low gray-level emphasis, SRHGE: Short-run high gray-level emphasis, LRGLE: Long-run low gray-level emphasis, LRHGE: Long-run high gray-level emphasis, GLNU: Gray-level nonuniformity, RLNU: Run-length nonuniformity, RP: Run percentage, NGDLM: Neighborhood gray-level different matrix, GLZLM: Gray-level zone length matrix, SZE: Short-zone emphasis, LZE: Long-zone emphasis, LGZE: Low gray-level zone emphasis, HGZE: High gray-level zone emphasis, SZLGE: Short-zone low gray-level emphasis, SZHGE: Short-zone high gray-level emphasis, LZGLE: Long-zone low gray-level emphasis, LZHGE: Long-zone high gray-level emphasis, ZLNU: Zone length nonuniformity, ZP: Zone percentage, AUC: Area under the curve, PET: Positron-emission tomography, CT: Computed tomography, CSH: : Cumulative standardized uptake value (SUV)-volume histogram , CAS: Calcium Agatston Score, TLG: Total Lesion Glycolysis, RIM: Radial Intensity Mean