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Expression changes of proinflammatory cytokines in cochlear tissues in the different groups. The expression levels of IL-6, TNF-α, and COX-2 in cochlear tissues were all significantly increased on day 7 and day 14 after radiation (all compared with WT groups), and all these significant changes after radiation were ameliorated by JSH-23 pretreatment (comparisons between the Rad and JSH-23 groups) * = P ≤ 0.05; ** = P ≤ 0.01; *** = P ≤ 0.001.
