Table 3.
Prognostic factors for overall survival and progression-free survival.
| Univariate Analysis | Multivariable Analysis | |||
|---|---|---|---|---|
| Variable and OS */PFS # | HR ° (95%CI §) | p-Value | HR ° (95%CI §) | p-Value |
| Variable and OS * | ||||
| Age | 1.172 (1.007–1.364) | 0.041 | 1.377 (1.053–1.800) | 0.020 |
| Gender | 34.023 (NA †) | 0.294 | ||
| pT-stage | 1.132 (0.459–2.789) | 0.788 | ||
| pN-stage | 0.326 (0.125–0.854) | 0.023 | 5.047 (1.194–21.341) | 0.028 |
| p-Stage | 2.177 (0.883–5.370) | 0.091 | ||
| Pathology | 1.884 (0.544–6.528) | 0.318 | ||
| Adenocarcinoma Grading | 4.039 (0.725–22.504) | 0.111 | ||
| CTCs a count (absolute number) | 0.911(0.715–1.161) | 0.452 | ||
| CTCs a count (>3 vs. < 3/mL blood) | 1.247 (0.311–4.990) | 0.755 | ||
| CTCs a TTF1+ b | 40.082 (NA †) | 0.275 | ||
| Variable and PFS # | ||||
| Age | 1.176 (0.941–1.470) | 0.154 | ||
| Gender | 36.380 (NA †) | 0.433 | ||
| pT-stage | 3.313 (1.291–8.502) | 0.013 | 0.151 | |
| pN-stage | 15.235 (NA †) | 0.198 | ||
| p-Stage | 8.122 (1.129–58.429) | 0.037 | 0.081 | |
| Pathology | 1.414 (0.246–8.123) | 0.698 | ||
| Adenocarcinoma Grading | 4.043 (0.599–27.309) | 0.152 | ||
| CTCs a count (absolute number) | 0.804 (0.514–1.257) | 0.339 | ||
| CTCs a count (>3 vs. <3/mL blood) | 0.404 (0.042–3.894) | 0.433 | ||
* OS, overall survival; # PFS, progression-free survival; ° HR, hazard ratio; § CI, confidence interval; † NA, not applicable; a CTCs, circulating tumor cells; b TTF-1, thyroid transcription factor-1.