Figure 7.

A global view of the main aspects and implications discussed in this work. As showed prior, a first episode of psychosis in pregnancy entails multiple challenges for healthcare professionals. This is because both the symptoms or possible interventions may have detrimental consequences for both the fetus and the mother. In the present work, we have demonstrated that the placentas of these women present an increased gene and protein expression of different components that are directly involved in the regulation of ferroptosis and lipid peroxidation. This fact, together with an increased detection of ferric ions, may be an indicator of iron accumulation in the placenta, thereby defining a possible pathophysiological role from these disturbances.