Table 1.
Top altered metabolites identified from the integrated metabolomics and lipidomics data set a.
| Class | Subclass | Metabolite or Lipid Name | HMDB or Lipid Maps ID | VIP Score | F.C. b | FDR p-Value c |
MWW p-Value d |
|---|---|---|---|---|---|---|---|
| Fatty acyls | Fatty acids and conjugates | Hydroxyisovaleric acid | HMDB0000754 | 1.21 | 4.11 | 2.10 × 10−9 | 1.58 × 10−6 |
| Unsaturated fatty acids | Tricosenoic acid | LMFA01030091 | 1.20 | 0.17 | 1.74 × 10−15 | 1.71 × 10−22 | |
| Fatty acyl glycosides | Methyl-butenoyl-apiosylglucose | HMDB0039952 | 1.21 | 10.70 | 1.62 × 10−39 | 6.32 × 10−15 | |
| Fatty acyl glycosides | Gingerdiol -beta-glucopyranoside | HMDB0036123 | 1.20 | 8.88 | 5.84 × 10−46 | 7.74 × 10−17 | |
| Fatty acid esters | Dimethylnonanoyl carnitine | HMDB0006202 | 1.19 | 0.04 | 2.15 × 10−35 | 5.71 × 10−14 | |
| Glycerophos-pholipids | Glycerophosphoinositols | PI (36:4) | HMDB0009899 | 1.19 | 0.37 | 1.90 × 10−13 | 6.15 × 10−10 |
| Glycerophosphates | LysoPA (18:3) | HMDB0114743 | 1.19 | 4.60 | 1.17 × 10−36 | 5.67 × 10−9 | |
| Carbohydrates and carbohydrate conjugates | Glucose-1-phosphate | HMDB0001586 | 1.21 | 0.22 | 9.33 × 10−14 | 6.15 × 10−9 | |
| Pteridines and derivatives | Alloxazines and isoalloxazines | Riboflavin | HMDB0000244 | 1.21 | 8.18 | 9.29 × 10−50 | 2.00 × 10−22 |
| Saccharolipids | Diacylaminosugars | UDP-(beta-hydroxymyristoyl)-GlcNAc | LMSL01020003 | 1.19 | 0.15 | 8.85 × 10−11 | 1.70 × 10−17 |
a Selected metabolites had a VIP > 1.19, a fold change > 1.5, and a Benjamini-Hochberg corrected p-value < 0.01; b Fold change (FC) defined as ethanol/control; c false-discovery rate (FDR) corrected p-value using the Benjamini-Hochberg method d Mann–Whitney U test or Wilcoxon Rank Sum Test p-value.