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. 2022 Dec 30;11(1):103. doi: 10.3390/biomedicines11010103

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Measurable 30 HZ Flicker-ERG after gene therapy with voretigene neparvovec. Upper Panel (A,B) shows Flicker-ERG of a 4-year-old male (P1) taken before therapy. Both in the right (A) and left (B) eye only background noise could be recorded even at high magnification of 10X (shown is the 5X magnification). After gene therapy, 30 Hz flicker responses could be obtained in the right eye (shown is a magnification of 4X) (C). Flicker responses of the left eye could not be properly evaluated due to compliance-related poor recording quality (D). Lower panel (E,F) shows 30 Hz flicker ERG of the left eye in a 5-year-old child (P3) at 10X magnification. Before gene therapy, only background noise was recordable (E). After gene therapy, reproducible 30 Hz flicker responses could be recorded in the left eye (F).