Figure 5.

Vision-related behavioral and psychometric changes after gene therapy. (A,B) show the reported responses to questions of the VFQ25 on certain activities that require good eyesight (A) and to questions about things whose performance may be affected by vision (B). Responses before therapy (ante) are represented by red columns, whereas the turquoise columns represent responses given 6 months after gene therapy (post). Individual scores for each patient and item ranged from 0 (representing the worst possible answer) to 4 (most positive answer as one would expect from a normally sighted person). Illustrated are the mean scores of each item for P1–P4 (n = 4). All items showed a clear increase in score and thus an improvement of the visual ability was reported by all patients and their parents, respectively.