Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 1;11(1):112. doi: 10.3390/biomedicines11010112

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effect of Lenvatinib on ex vivo on−gel sequential hybrid co−culture of HUVEC on Patient−Derived primary ovarian CAF for 4 h: We performed sequential Hybrid Co-Culture of HUVEC on Patient-Derived primary ovarian CAF for 4 h on-gel following lenvatinib (A). Angiogenic Scores (B) are determined by the polygons, junctions, and CAF clusters (as represented by rectangular/square boxes in photomicrographs of A) as well as angiogenic endpoints and mean E lacunarity (C). Matrigel tube formation assay of HUVECs cultured in HyCC format with patient-derived ovarian CAFs in control medium (green) or in the presence of 1 microM of lenvatinib (red) for 4 h. Angiogenic Endpoints (total number) (represented in Divot bars) and the mean E lacunarity (represented in 40% filled bars) were detected with the AngioTool software (https://ccrod.cancer.gov/confluence/display/ROB2/Home [(accessed on 9 August 2022)]). Bars represent the mean and standard deviation of the mean.

Effect of Lenvatinib on ex vivo on−gel sequential hybrid co−culture of HUVEC on Patient−Derived primary ovarian CAF for 4 h: We performed sequential Hybrid Co-Culture of HUVEC on Patient-Derived primary ovarian CAF for 4 h on-gel following lenvatinib (A). Angiogenic Scores (B) are determined by the polygons, junctions, and CAF clusters (as represented by rectangular/square boxes in photomicrographs of A) as well as angiogenic endpoints and mean E lacunarity (C). Matrigel tube formation assay of HUVECs cultured in HyCC format with patient-derived ovarian CAFs in control medium (green) or in the presence of 1 microM of lenvatinib (red) for 4 h. Angiogenic Endpoints (total number) (represented in Divot bars) and the mean E lacunarity (represented in 40% filled bars) were detected with the AngioTool software (https://ccrod.cancer.gov/confluence/display/ROB2/Home [(accessed on 9 August 2022)]). Bars represent the mean and standard deviation of the mean.