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. 2023 Jan 1;11(1):112. doi: 10.3390/biomedicines11010112

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of Lenvatinib on ex vivo on−gel sequential hybrid co−culture of HUVEC on Patient−Derived primary ovarian CAF for 18 h: We performed sequential Hybrid Co-Culture of HUVEC on Patient-Derived primary ovarian CAF for 18 h on-gel following lenvatinib (A). Angiogenic Scores (B) are determined by the polygons, junctions, and CAF clusters as well as angiogenic endpoints and mean E lacunarity (C). Matrigel tube formation assay of HUVECs cultured in HyCC format with Patient-Derived ovarian CAFs in control medium (green) or in the presence of 1 microM of lenvatinib (red) for 18 h. Angiogenic Endpoints (total number) (represented in Divot bars) and the mean E Lacunarity (represented in 40% filled bars) were detected with the AngioTool software (https://ccrod.cancer.gov/confluence/display/ROB2/Home [(access on 9 August 2022)]). Bars represent the mean and standard deviation of the mean.

Effect of Lenvatinib on ex vivo on−gel sequential hybrid co−culture of HUVEC on Patient−Derived primary ovarian CAF for 18 h: We performed sequential Hybrid Co-Culture of HUVEC on Patient-Derived primary ovarian CAF for 18 h on-gel following lenvatinib (A). Angiogenic Scores (B) are determined by the polygons, junctions, and CAF clusters as well as angiogenic endpoints and mean E lacunarity (C). Matrigel tube formation assay of HUVECs cultured in HyCC format with Patient-Derived ovarian CAFs in control medium (green) or in the presence of 1 microM of lenvatinib (red) for 18 h. Angiogenic Endpoints (total number) (represented in Divot bars) and the mean E Lacunarity (represented in 40% filled bars) were detected with the AngioTool software (https://ccrod.cancer.gov/confluence/display/ROB2/Home [(access on 9 August 2022)]). Bars represent the mean and standard deviation of the mean.