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. 2022 Dec 26;13(1):43. doi: 10.3390/biom13010043

Figure 11.

Figure 11

The effect of super enhancer on RAB42 expression. (A) ChIP-seq profiles of H3K27ac signal in RAB42 gene loci in different tumor cells. (B) The relative RAB42 expression was deter-mined in gastric cancer cells by qPCR. (C) The relative enrichment levels of H3K27ac to RAB42 gene loci by ChIP-qPCR. (D) Correlation between BRD4 and RAB42 expression in STAD using the GEPIA database. (E) The relative enrichment levels of BRD4 to RAB42 gene loci by ChIP-qPCR. (F) The relative RAB42 expression after the treatment with JQ1 (1uM) and I-BET-762 (2uM) by qPCR. (G) The relative RAB42 expression after BRD4 knockdown by qPCR. *p < 0.05, **p < 0.01, ***p < 0.001, and **** p < 0.0001.