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. 2022 Dec 29;13(1):53. doi: 10.3390/bios13010053

Table 24.

Advantages and limitations of CRISPR-dCas9-mediated sensing.

Advantages Limitations

  • Very high sensitivity and specificity [143]

  • Multiplexable

  • Good nucleic acid probe stability

  • Limited to nucleic acid targets

  • Requires many assay reagents

  • Expensive reagents

  • Limited precedent for use