Table 1.

Data for the recovery of total cellular ATP levels in sPD fibroblast lines (mean data across 3 sPD lines) and LRRK2G2019S mutant fibroblast lines (mean data across 3 LRRK2 fibroblast lines).

Compound	sPD		LRRK2
	Maximal Response [%] 1	logEC50 2	Maximal Response [%] 1	logEC50 2
UDCA	165	−7.1	127	−8.4
3	230	-6	141	−9.3
4	125	−8.6	173	−8
7	132	−8.9	147	−7.7
24	143	−9.1	140	−8.1

¹ The [%] maximal response is the maximum recovery effect of each compound reached across the nine-point concentration response curve. ² LogEC₅₀ give the LogEC₅₀ concentration achieved by each compound in those lines. Compounds 4, 7 and 24 have lower EC₅₀ concentrations in both the sPD and LRRK2 fibroblast lines compared to UDCA, whereas 3 has a higher maximal effect in both sPD and LRRK2 fibroblast lines. Indeed, all compounds have higher maximal effect than UDCA in the LRRK2 mutant fibroblasts. 100% is the DMSO vehicle-treated ATP level of the patient fibroblast lines. An increase of up to 130% would restore the ATP levels in these fibroblast lines to control levels.