Table 1.

Significantly altered metabolites, detected by GC-MS, between patients with prostate cancer and healthy control subjects.

Category	Compound	RT	%Δ	FC	log2FC	pBH	VIP
Fatty Acyls	Caprylic acid (octanoic acid)	9.79	41.43	1.41	0.50	<0.0001	1.17
	Caproic acid (hexanoic acid)	7.06	−68.94	0.31	−1.69	<0.0001	2.04
	Lauric acid (dodecanoic acid)	14.75	69.22	1.69	0.76	0.002	1.00
	Palmitic acid (hexadecanoic acid)	18.87	92.58	1.93	0.95	<0.0001	1.06
	Stearic acid (octadecanoic acid)	20.69	80.19	1.80	0.85	0.002	1.02
	Palmitoleic acid (hexadecenoic acid)	18.68	181.07	2.81	1.49	<0.0001	1.00
	Linoleic acid (octadecadienoic acid)	20.41	140.74	2.41	1.27	<0.0001	1.02
	Oleic acid (octadecenoic acid)	20.46	177.32	2.77	1.47	<0.0001	1.07
Organic acids and derivatives	Lactic acid (2-hydroxypropanoic acid)	6.85	−56.24	0.44	−1.19	<0.0001	3.96
	2-hydroxybutyric acid	7.79	87.56	1.88	0.91	<0.0001	1.09
	3-hydroxybutyric acid	8.28	257.75	3.58	1.84	<0.0001	1.58
	Pyruvic acid (2-oxopropanoic acid)	6.70	−65.78	0.34	−1.55	<0.0001	2.04
	2-ketoisocaproic acid (ketoleucine)	8.54	33.61	1.34	0.42	0.049	1.03
Carbohydrates and carbohydrate conjugates	Glycerol	9.87	69.00	1.69	0.76	<0.0001	1.08
	Glyceric acid	10.65	30.93	1.31	0.39	0.002	1.00
	Mannose	17.22	19.80	1.20	0.26	0.002	1.02
	Galactose/glucose	17.55	17.57	1.18	0.23	0.002	1.66
Sterol Lipids	Cholesterol	27.57	30.47	1.30	0.38	0.003	1.04

%Δ, percentage of change; FC, fold change; pBH, Benjamini–Hochberg adjusted p-value; RT, retention time; VIP, variable importance in the projection.