AEs	adverse events
AKT	protein kinase
BC	breast cancer
CDK4/6	cyclin-dependent kinases 4 and 6
CT	circulating tumor
EGFR	epidermal growth factor receptor
ER	estrogen receptor
ET	endocrine therapy
FFPE	formalin-fixed paraffin-embedded
GPCR	G-protein-coupled receptor
HR	hazard ratio
HER2	human epidermal growth factor receptor 2
HER2+	human epidermal growth factor receptor 2 positive
HER2−	human epidermal growth factor receptor 2 negative
HR+	hormone receptor positive
IGF-1R	insulin-like growth factor-1 receptor
MBC	metastatic breast cancer
mPFS	median progression free survival
mTOR B	mammalian target of rapamycin
NGS	Next-Generation-Sequencing
ORR	objective response rate
OS	overall survival
pCR	pathological complete response
PCR	polymerase chain reaction
PDGFR	platelet-derived growth factor receptor
PI3K	phosphoinositide 3-kinase
PIP2	Phosphatidylinositol-4,5-bisphosphate
PIP3	Phosphatidylinositol-3,4,5-trisphosphate
PTEN	tensin homolog
RTK	tyrosine kinases receptor