OA	Osteoarthritis
CRGs	Cuproptosis-related genes
GEO	Gene-expression omnibus
ssGSEA	Single-sample gene-set enrichment analysis
RF	Random forest
PPI	Protein–protein interaction
RT-qPCR	Real-time quantitative PCR
ROC	Receiver operating characteristic;
BP	Biological process
CC	Cellular component
MF	Molecular function
KEGG	Kyoto Encyclopedia of Genes and Genomes
DSigDB	Drug signatures database
NK	Natural killer
TIL	Tumor-infiltrating lymphocytes
APC	Antigen-presenting cell
HLA	Human leukocyte antigen
IFN	Type I interferon
CCR	Cytokine–cytokine receptor interaction
TCA	Tricarboxylic acid
DBT	Dihydrolipoamide branched chain transacylase E2
DLST	Dihydroli-poamide S-succinyltransferase
FDX1	Ferredoxin 1, a direct target of copper ionophores
LIPT1	Lipolytransferase 1