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. 2023 Jan 7;13(1):123. doi: 10.3390/biom13010123

Figure 2.

Figure 2

miR-146a-5p is induced by IL-1β in murine articular chondrocytes and is elevated in human OA cartilage. (a) MA plot of miRNA expression profiling from microRNA-Seq (miRNA-Seq) assays with IL-1β or vehicle-treated primary murine articular chondrocytes. Differentially expressed genes (DEGs) (Log2FoldChange > 0.3, Padj < 0.05) between IL-1β and vehicle groups were highlighted in blue (n = 4); (b) Real-time qPCR for miR-146a-5p in IL-1β- or vehicle-treated primary murine articular chondrocytes (n = 3); (c) Fluorescent in situ hybridization (FISH) for miR-146a-5p on articular cartilage sections from healthy donors or OA patients (n = 3) (scale bar, 100 μm). Data presented as mean ± SD. * p < 0.05 by Student’s t-test.