Table 3.
Metabolites identified as significantly different in heart failure.
| Metabolite | Tstat | p Value | = –LOG(10p) | FDR |
|---|---|---|---|---|
| Symmetric dimethylarginine | −5.31 | 1.65 × 10−6 | 5.78 | 7.11 × 10−5 |
| Cholesteryl ester (18:2) | 5.06 | 4.15 × 10−6 | 5.38 | 9.13 × 10−4 |
| Sphingomyelin (42:1) | 4.91 | 7.19 × 10−6 | 5.14 | 8.13 × 10−4 |
| Sphingomyelin (40:4) | 4.82 | 1.00 × 10−5 | 5.00 | 8.13 × 10−4 |
| Sphingomyelin (38:1) | 4.52 | 2.88 × 10−5 | 4.54 | 1.75 × 10−3 |
| Triglyceride (55:9) | −4.52 | 2.91 × 10−5 | 4.09 | 7.07 × 10−3 |
| Sphingomyelin (40:2) | 4.23 | 8.05 × 10−5 | 4.09 | 3.91 × 10−3 |
| Creatinine | −4.22 | 8.44 × 10−5 | 4.07 | 1.82 × 10−3 |
| Sphingomyelin (40:1) | 4.06 | 1.44 × 10−4 | 3.84 | 3.51 × 10−2 |
| Sphingomyelin (33:2) | 4.04 | 1.50 × 10−4 | 3.82 | 6.06 × 10−3 |
| Phosphatidylcholine (34:5) | 3.98 | 2.18 × 10−4 | 3.66 | 2.01 × 10−2 |
| Lysophosphatidylcholine (18:2) | 3.89 | 2.53 × 10−4 | 3.60 | 8.77 × 10−3 |
| Phosphatidylcholine (30:0) | 3.90 | 2.80 × 10−4 | 3.55 | 2.01 × 10−2 |
| Sphingomyelin (33:1) | 3.89 | 2.94 × 10−4 | 3.53 | 2.01 × 10−2 |
| Phosphatidylcholine (30:0) | 3.81 | 3.79 × 10−4 | 3.42 | 2.15 × 10−2 |
| Phosphatidylcholine (39:3) | 3.75 | 3.89 × 10−4 | 3.41 | 1.18 × 10−2 |
| Phosphatidylcholine (35:5) | 3.60 | 6.31 × 10−4 | 3.20 | 1.67 × 10−2 |
| Phosphatidylcholine (34:2) | 3.56 | 7.30 × 10−4 | 3.14 | 1.67 × 10−2 |
| Phosphatidylcholine (32:3) | 3.52 | 8.13 × 10−4 | 3.09 | 1.67 × 10−2 |
| Phosphatidylcholine (36:5) | 3.52 | 8.25 × 10−4 | 3.08 | 1.67 × 10−2 |
| Phosphatidylcholine (36:2) | 3.49 | 1.00 × 10−3 | 3.00 | 3.28 × 10−2 |
| Arginine | 3.41 | 1.18 × 10−3 | 2.93 | 4.40 × 10−2 |
| Sphingomyelin (41:1) | 3.38 | 1.27 × 10−3 | 2.90 | 2.31 × 10−2 |
| Sphingomyelin (39:1) | 3.35 | 1.40 × 10−3 | 2.85 | 2.31 × 10−2 |
| Sphingomyelin (39:2) | 3.36 | 1.47 × 10−3 | 2.83 | 3.85 × 10−2 |
| Sphingomyelin (41:2) | 3.35 | 1.54 × 10−3 | 2.81 | 3.85 × 10−2 |
| Sphingomyelin (38:2) | 3.31 | 1.56 × 10−3 | 2.81 | 3.85 × 10−2 |
| Phosphatidylcholine (32:2) | 3.34 | 1.58 × 10−3 | 2.80 | 3.85 × 10−2 |
| Kynurenine | −3.25 | 1.91 × 10−3 | 2.72 | 2.74 × 10−2 |
| Sphingomyelin (31:1) | 3.25 | 2.05 × 10−3 | 2.69 | 4.65 × 10−2 |
| Cholesteryl ester (16:0) | 3.09 | 2.98 × 10−3 | 2.53 | 4.07 × 10−2 |
| Lysophosphatidylcholine (16:0) | 3.06 | 3.26 × 10−3 | 2.49 | 4.17 × 10−2 |
| Lysophosphatidylcholine (18:0) | 3.00 | 3.94 × 10−3 | 2.50 | 4.49 × 10−2 |
| Phosphatidylcholine (34:6) | 2.96 | 4.41 × 10−3 | 2.36 | 4.61 × 10−2 |
| Lysophosphatidylcholine (15:0) | 2.95 | 4.55 × 10−3 | 2.34 | 4.61 × 10−2 |
T stat = T statistic, FDR = False discovery rate.