Table 1.
Characteristic | Mean | Median | Range | N | (%) |
---|---|---|---|---|---|
Age, years | 64.9 | 67.7 | 18–98 | 1268 | 100 |
<65 | 540 | 42.6 | |||
≥65 | 728 | 57.4 | |||
Sex | 1268 | 100 | |||
Male | 712 | 56.2 | |||
Female | 556 | 43.8 | |||
ECOG | 1075 | 100 | |||
0 | 420 | 39.1 | |||
1 | 452 | 42.0 | |||
2 | 135 | 12.6 | |||
3 | 53 | 4.9 | |||
4 | 15 | 1.4 | |||
Not available | 193 | ||||
WBC (×109/L) | 32.8 | 8.8 | 0.24–407 | 1118 | |
BM blast cells, % | 53.4 | 52.0 | 0–100 | 1026 | |
Creatinine, mg/dL | 1.1 | 0.90 | 0.28–10.3 | 1071 | |
MRC cytogenetic profile | 1011 | 100 | |||
Favorable | 57 | 5.6 | |||
Intermediate | 178 | 17.6 | |||
Unfavorable | 269 | 26.6 | |||
Normal karyotype | 507 | 50.1 | |||
Not available | 257 | ||||
AML FAB subtype | 715 | 100 | |||
M0 | 88 | 12.3 | |||
M1 | 144 | 20.1 | |||
M2 | 126 | 17.6 | |||
M4 | 173 | 24.2 | |||
M5 | 144 | 20.1 | |||
M6 | 31 | 4.3 | |||
M7 | 9 | 1.3 | |||
Not available | 553 | ||||
Therapeutic approach | 1268 | 100 | |||
Intensive | 695 | 54.8 | |||
Non–intensive | 513 | 40.5 | |||
Supportive care only | 60 | 4.7 | |||
Type of AML | 1268 | 100 | |||
De novo | 920 | 72.6 | |||
Secondary | 348 | 27.4 |