Table 1.
Demographics for a three cohort study of proteomic expression
| OPDC-Serum | OPDC/TP-1K | PUKBB-Brain | OPDC-CSF | TP-Serum | |
|---|---|---|---|---|---|
| Total samples | 572 | 224 | 37 | 85 | 932 |
| Disease status Case (%) Control |
400 (69.9) 172 (30.1) |
159 (71) 65 (29) |
24 (64.9) 13 (35.1) |
70 (82.4) 15 (17.6) |
671 (81.9) 148 (18.1) |
| Sex (%) Male Female |
326 (57) 246 (43) |
161 (71.9) 63 (28.1) |
29 (78.4) 8 (21.6) |
53 (62.4) 32 (37.6) |
567 (60.8) 365 (39.2) |
| Cohort (%) | OPDC (100) | TP (35.7) OPDC (64.3) |
PUKBB (100) | OPDC (100) | TP (100) |
| Mean age at sampling [SD] (range) | All 66.8 [10.4] (28.5–90.9) Cases 68.6 [9.6] (32.2–90.9) Controls 62.4 [10.9] (28.5–88.9) |
All 70.4 [6.5] (53.6–83.5) Cases 70.4 [6.4] (53.6–83.5) Controls 70.6 [6.7] (54.7–83.4) |
All 78.9 [8.2] (58–91) Cases 79.2 [6] (63–90) Controls 78.2 [11.4] (58–91) |
All 65.9 [8.6] (39.7–85.1) Cases 65.8 [8.8] (39.7–83.6) Controls 66.1 [7.9] (55.3–85.1) |
All 66.4 [9.3] (33.5–87.4) Cases 66.9 [8.8] (37–85.6) Controls 62.1 [9.7] (36.9–87.4) |
| Mean LEDD dosage at time of sampling* [SD] (range) | 352.9 [263.9] (0–1450) | 302.1 [197.5] (0–1310) | 403.5 [324.2] (0–1100) | 326.3 [258.3] (0–1120) | 283.3 [200.6] (0–1380) |
| Mean MoCA score at sampling [SD] (range) | All 25 [3.5] (10–30) Cases 24.2 [3.5] (10–30) Controls 26.8 [2.7] (15–30) |
All 24.3 [4.7] (10–30) Cases 23.8 [5.1] (10–30) Controls 25.7 [3.1] (16–30) |
- | All 25.7 [3.1] (17–30) Cases 25.3 [3.1] (17–30) Controls 27.5 [2.1] (23–30) |
All 25.1 [4.1] (0–30) Cases 25.3 [3.2] (13–30) Controls 24.4 [7.1] (0–30) |
| Mean UPDRS3 score at sampling [SD] (range) | All 20 [15.3] (0–78) Cases 27.8 [11.3] (4–78) Controls 1.8 [2.9] (0–19) |
All 19.8 [18.2] (0–74) Cases 26.8 [16.9] (1–74) Controls 2.3 [2.9] (0–13) |
- | All 22.9 [14.4] (0–74) Cases 27.4 [11.6] (10–74) Controls 2.3 [2.9] (0–9) |
All 19.7 [13.3] (0–70) Cases 22.5 [12] (1–70) Controls 3.6 [5.4] (0–38) |
MoCA and UPDRS III score not available for brain bank samples.
CSF, cerebrospinal fluid; LEDD, levodopa equivalent daily dose; OPDC, Oxford Parkinson’s Disease Centre; TP, tracking Parkinson's; PUKBB, Parkinson’s UK Brain Bank; SD, standard deviation. *LEDD values for cases only.