Table 3.
WGCNA protein modules with endophenotype relationships
| Parkinson’s disease Status (P-value) | UPDRS (P-value) | MOCA (P-value) | Severity score (P-value) | Total proteins | Hub proteins | Enriched KEGG pathways | |
|---|---|---|---|---|---|---|---|
| MEred | 0.034 | 0.001 | 0.004 | 0.0003 | 142 | APEX1 DNA−(apurinic or apyrimidinic site) lyase (APEX1) | Spliceosome |
| MEturquoise | 4.09 × 10−7 | 4.63 × 10−5 | 0.007 | 6.79 ×10−7 | 704 | Neurogenic locus (NOTCH1) | Complement and coagulation cascades, axon guidance |
| MEyellow | 0.012 | 0.011 | 0.008 | 0.0005 | 98 | HPGD 15-HPDG [NAD(+)] | Parkinson’s disease, oxidative phosphorylation, apoptosis |
Modules with significant correlation with all disease phenotype were selected for further analysis. The three modules described passed P-value thresholds (adjusted P < 0.05) and had functional relevance.